Department of Neurology, Gentofte Hospital, Hellerup, Denmark.
Pain, tenderness, wheal and flare induced by substance-P, bradykinin and 5-hydroxytryptamine in humans.
Cephalalgia. 11(4):175-82, 1991 Sep.
Abstract:
The algesic effect of substance-P with and without the addition of bradykinin or 5-hydroxytryptamine was studied in 13 healthy volunteers. Test substances dissolved in saline were injected into the temporal muscle and the forearm skin and the effects compared with those of saline. In the temporal muscle, none of the test substances induced more pain than saline, but substance-P with bradykinin lowered the pressure pain threshold by 18% (p less than 0.02). All test substances induced pain wheal and flare in the forearm skin. Substance-P induced a more pronounced flare reaction than bradykinin, whereas the latter induced more pain than substance-P. This dissociation between pain and flare may indicate that C-fibres in the human skin represent more than one type of nociceptor.
The effect of serotonin antibodies on the development of a neuropathic pain syndrome]. [Russian]
Patologicheskaia Fiziologiia i Eksperimentalnaia Terapiia. (2):6-8, 1997 Apr-Jun.
Abstract:
Serotoninergic and catecholaminergic neurotransmitter systems of the brain play an important role in the regulation of pain sensitivity. However, there are no data on the involvement of antibodies to the above neurotransmitters is the development of neuropathic pain syndromes. The authors' studies indicated that the development of neuropathic pain syndrome occurring after nerve damage is followed by the formation of serotonin antibodies and their enhanced induction caused by immunization of animals with serotonin-protein conjugated antigen aggravates the pain syndrome. Block and insufficiency of the serotoninergic antinociceptive system may be a cause of the progression of the pain syndrome due to serotonin antibodies.
